Leading the way to Healthy Aging
About Domenico Pratico, MD
Domenico Pratico’s, MD, research area is clinical pharmacology with a special focus on the cellular and molecular aspects of cell oxidative biology and a particular interest in small molecules such as bioactive oxidized lipids.
This area is very broad and extends to multiple disciplines including aging, cardiovascular diseases as well as neurodegeneration.
Our work in the biology of oxidized bioactive lipids has significantly contributed to the current understanding of their importance as biomarkers, mediators of cellular and molecular events involved in the pathogenesis of several clinical conditions, and therapeutic targets for preventing and treating human diseases.
In our lab, we employ cellular and animal models of human diseases, and in this context particular emphasis is given to the translation of any observation made in these systems into a better understanding of human physiology and pathology.
Lauretti, E., Dabrowski, K., Praticò, D. The neurobiology of non-coding RNAs and Alzheimer's disease pathogenesis: pathways, mechanisms, and translational opportunities.
Filippone, A., Li, JG., Praticò, D. VPS35 downregulation alters degradation pathways in neuronal cells.
Lyssenko N, Praticò, D. ABCA7 and the altered lipidostasis hypothesis of Alzheimer’s disease. Alzheimer’s & Dementia.
Filippone, A., Praticò, D. Endosome dysregulation in Down syndrome: a potential contributor to Alzheimer's disease pathology.
Extra virgin olive oil and brain health (Alzheimer's disease)
Domenico Pratico, MD, FCPP, Director of the University's Alzheimer Center Temple, USA. Professor of Neuroscience at Temple University.Extra virgin olive oil and brain health (Alzheimer's disease)